The rootin'-tootin' titular siblings of
The Sisters Brothers are two men who have developed a reputation for being handy with a gun and getting whatever assignment you give them finished, albeit finished in an unconventional manner. These two men are Eli Sisters (John C. Reilly) and Charlie Sisters (Joaquin Phoenix), with the former member of the duo looking to find a way out of this life of being a gun-for-hire for bloodthirsty rich folks while Charlie Sisters see's no other life for himself and his brother than the one they're engaging in right now. Meanwhile, a pivotal subplot involves another duo, this time consisting of Southern dandy John Morris (Jake Gyllenhaal) and chemist Kermit Warm (Riz Ahmed), with Morris teaming up with Warm for a potentially lucrative prospecting gig after he was initially hired to hold Warm hostage for the Sisters Brothers.
