We begin Mikey and Nicky in media res. Something has gone horribly wrong. Nicky (John Cassavetes) is alone in a hotel room profusely sweating after learning a hit has been put out for him. There's only one person he can turn to: his life-long friend Mikey (Peter Falk). Considering they've been pals since childhood, Nicky gives Mikey a ring and asks him to come to the hotel room and help him out of this jam. It isn't long before Mikey arrives and tries to talk Nicky down from his hysterical state. The two proceed to create a plan for Nicky to leave town, but before he can do that, Nicky insists the two friends spend the rest of the night in New York City doing whatever comes into his head.
