Michael (Mark Duplass) and Andy (Ray Romano) are an unexpected pair of buddies. They're apartment neighbors, with Andy living above Michael, and they've gradually become friends who bond over classic martial arts move, homemade pizzas and a game they created called Paddleton. Once the movie Paddleton begins, though, that friendship is threatened by Michael contacting a life-threatening disease that can't be cured. Death is unavoidable and now these two pals are looking to make the best of whatever time they have left, which will include a road trip to procure some extremely rare medicine for Michael.
